Methylation Detection CapitalBio

Generally, the quantitative detection of a large sample is required for WGBS or the differential methylation loci found in chip detection, or the specific area of the candidate gene. On basis of the AgenaMassARRAY® mass spectrometry platform, CapitalBio Technology can offer the quantitative detection service for methylation loci in candidate areas. On the premise of guaranteed accuracy, sensitivity, and reliability, this technology can realize the detection of the methylation level of all CpG loci in DNA fragments within 600 bp through a one-off reaction.

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Medicine

Research on disease mechanism

Molecular marker of disease

Regulation of gene expression

Research on complex diseases

Agriculture

Ontogeny and cell differentiation of animals and plant

Animal and plant breeding

Species and population evolution

Agena Massarray Mass Spectrometry Platform Experiment Process Advantages Specifications

High performance	It can analyze multiple CpG loci within 600bp and be compatible with FFPE sample
High accuracy	Direct detection of molecular weight without further verification of data
Good repeatability	CV≤5%
Cost effectiveness	Support detection to multiple CpG loci in one amplicon
Convenient	Visible data output, clear view of detection results

Sample Requirements	Purity:OD260/280 is within the range of 1.7-2.1
	DNA amount ≥1μg
	DNA concentration ≥20ng/μL
	Integrity:main band of genome is clear and free from RNA contamination, protein contamination or degradation, with molecular weight ≥10Kb.