Genes are internal factors that affect or even determine human health, and genes associated with the disease are called disease susceptibility genes. Due to the differences between the genes of different individuals, some people are naturally prone to certain diseases, that is, they carry susceptibility genotypes related to the occurrence of diseases. When these susceptible people are exposed to adverse factors in the environment, their disease incidence rate is higher than people who do not carry the disease susceptibility genotype. Therefore, during precise healthcare sequencing solutions understanding the disease susceptibility genes in the human body can help predict the risk of disease occurrence.